Influence of erdosteine, a mucolytic agent, on amoxycillin penetration into sputum in patients with an infective exacerbation of chronic bronchitis.

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Influence of erdosteine, a mucolytic agent, on amoxycillin penetration into sputum in patients with an infective exacerbation of chronic bronchitis.

Twenty four patients with acute infective exacerbations of chronic bronchitis received amoxycillin alone or in combination with erdosteine (a mucolytic agent) for a week in a double blind, placebo controlled study. Clinical assessment scores, body temperature, serum and sputum amoxycillin concentrations, and sputum culture results were recorded in each group. Erdosteine significantly increased ...

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Rheological assessment of mucolytic agents on sputum of chronic bronchitics.

In vitro and in vivo studies were made on the sputum of chronic bronchitics using a FerrantiShirley cone and plate viscometer and a new stress relaxation method. The latter utilized a modified chemical balance and permitted study at very low shear rates. The results from simpler apparatus correlated well with the data obtained with the cone and plate viscometer. Significant reduction in four ch...

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Pathogenic organisms in the sputum of patients with chronic bronchitis.

Bacteriological examination of the early morning sputum from 54 patients with chronic bronchitis, half of whom received chemoprophylaxis with oxytetracycline, was made regularly for periods up to four and a half years. Nasal and perineal swabs were taken for periods up to three and a half years. There was no evidence that frequent or dangerous proliferation of drug-resistant organisms occurred ...

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ژورنال

عنوان ژورنال: Thorax

سال: 1988

ISSN: 0040-6376

DOI: 10.1136/thx.43.8.585